吳清平; 肖春; 楊小兵; 張菊梅
廣東省微生物研究所廣東省菌種保藏與應(yīng)用重點(diǎn)實(shí)驗(yàn)室廣東省微生物應(yīng)用新技術(shù)公共實(shí)驗(yàn)室; 中國(guó)科學(xué)院南海海洋研究所; 中國(guó)科學(xué)院研究生院
【中文摘要】 綜述了食(藥)用菌來(lái)源的多糖類降血糖活性物質(zhì)的種類和作用機(jī)理,比較了降血糖活性成分對(duì)糖尿病模型小鼠的作用。食(藥)用菌多糖類物質(zhì)對(duì)糖尿病小鼠的血糖降低率多在20%65%之間;這些活性物質(zhì)可以通過(guò)升高胰島素的含量,也可通過(guò)調(diào)節(jié)與糖代謝相關(guān)酶的活性而促進(jìn)葡萄糖的氧化利用,還可通過(guò)改善胰島素抵抗等降低血糖。筆者認(rèn)為深入研究降血糖活性物質(zhì)的結(jié)構(gòu)以及構(gòu)效關(guān)系,將有助于食(藥)用菌降血糖活性物質(zhì)的開(kāi)發(fā)應(yīng)用。
【英文摘要】 The hypoglycemic effects of components extracted from edible and medicinal fungi and their mechanisms of action are described.Mushroom extracts are reported to decrease plasma(serum) glucose levels in animal models by 20%65% through a variety of mechanisms including increased insulin levels,regulation of the activities of sugar-metabolizing enzymes,accelerated oxygenation of glucose,and enhanced insulin sensitivity.We conclude that further studies on structure-function relationships are required to ensure the future development and application of bioactive hypoglycemic components from edible and medicinal fungi.
【中文關(guān)鍵詞】 食(藥)用菌; 多糖; 降血糖活性; 降血糖機(jī)理
【英文關(guān)鍵詞】 Edible fungi; polysaccharide; hypoglycemic effect; hypoglycemic mechanism
【基金】國(guó)家發(fā)改委生物高技術(shù)產(chǎn)業(yè)化項(xiàng)目“南方食用菌優(yōu)良新品種繁育和產(chǎn)業(yè)化示范”[編號(hào):發(fā)改辦高技(2008)1136號(hào)];; 廣東省科技計(jì)劃重點(diǎn)項(xiàng)目“食用菌產(chǎn)業(yè)推進(jìn)關(guān)鍵技術(shù)研究與示范”(編號(hào):2008A020100024)的部分研究?jī)?nèi)容
【文獻(xiàn)出處】 食用菌學(xué)報(bào),Acta Edulis Fungi,編輯部郵箱,2009年03期 【DOI】CNKI:SUN:SYJB.0.2009-03-020